Publications
A collection of my research work.
Enhancing pan-cancer spatial transcriptomics at single-cell resolution with stPainter
Yuhang Yang*, Yiming Luo*, Kai Zhang†, Zaixi Zhang, Haoxin Peng, Chenlin Cao, Qi Liu, Bin Ma, Yang Chen†, Lin Shen†, Enhong Chen†
Nature Communications 2026
A method that enhances pan-cancer spatial transcriptomics to single-cell resolution, recovering fine-grained cellular structure across diverse tumor tissues.
Benchmarking LLM Agents on Real-World Biological Database Curation for Data-Driven Scientific Discovery
Jiaxian Yan, Xi Fang, Jintao Zhu, Chenmin Wu, Yuhang Yang, Chenxi Du, Meijing Fang, Kai Zhang, Zaixi Zhang, Qi Liu†
KDD 2026
A benchmark that evaluates LLM agents on real-world biological database curation tasks for data-driven scientific discovery.
DriftST: One-Step Generative Inference of Spatial Transcriptomics from H&E Histology
Yuhang Yang*, Yonggan Bu, Shengyuan Zhou, Yiming Luo, Kai Zhang†
arXiv 2026
A one-step generative framework that infers spatially resolved gene expression from H&E histology images, unifying spot-level and cell-level prediction.
Reconstructing True 3D Spatial Omics at Single-Cell Resolution
Yuhang Yang*, Yiming Luo*, Kai Zhang†, Yonggan Bu, Zheng Xia, Haoxin Peng, Rui Yan, Qi Liu, Yang Chen†, Lin Shen†, Enhong Chen†
bioRxiv 2026
A computational framework that reconstructs true 3D spatial omics at single-cell resolution, assembling 2D tissue slices into faithful three-dimensional molecular maps.
CeProAgents: A Hierarchical Agents System for Automated Chemical Process Development
Yuhang Yang*, Ruikang Li*, Kai Zhang†, Jifei Ma, Yonggan Bu, Qi Liu, Jibin Zhou, Enhong Chen†
arXiv 2026
A hierarchical multi-agent system that automates chemical process development by coordinating specialized LLM-based agents across reasoning, planning, and execution.
BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature
Jiaxian Yan*, Jintao Zhu*, Yuhang Yang, Qi Liu†, Kai Zhang, Zaixi Zhang, Xukai Liu, Boyan Zhang, Kaiyuan Gao, Jinchuan Xiao, Enhong Chen
bioRxiv 2025
A multi-modal system that automatically mines protein-ligand bioactivity data from the scientific literature by jointly understanding text and figures.